Artigo publicado 1979 associava a fosfoetanolamina com o crescimento tumoral em ratos

fosfoetanolamina estudo 1979


 

Resultados apresentados em um artigo publicado, em 1 de novembro de 1979, sobre a fosfoetanolamina relacionava o uso da substância com o crescimento do carcinoma mamário em ratos. Além do resultado controverso, alguns profissionais afirmam que o estudo conduzido em 1979 não é conclusivo.

 

Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat

Kano-Sueoka T, Cohen DM, Yamaizumi Z, Nishimura S, Mori M, Fujiki H.

Abstract

We have identified phosphoethanolamine as the pituitary-derived growth-promoting material that specifically stimulates the rat mammary carcinoma cell line 64-24. We have been studying the growth characteristics of the 64-24 cell line, which was isolated from a highly hormone-dependent tumor and which retains in culture many characteristics of the original tumor. Previously, crude bovine pituitary extract was shown to contain a significant amount of growth-stimulating activity for these cells, and a growth factor from this extract was purified to homogeneity. This report describes the identification of the growth factor as phosphoethanolamine. Further, the biological activity of phosphoethanolamine was found to be virtually identical to that of the purified growth factor. A possible role of phosphoethanolamine in the growth of mammary tumor cells as well as of normal mammary epithelial cells and other tissues is discussed.

 

PubMed ID293677
Publication HistoryPublished on November 1, 1979

 

Você pode conferir o artigo completo no link - http://www.pnas.org/content/76/11/5741.full.pdf